Log In|Sign Up
EN
The coding sequence of the first translated exon of the mouse gene (exon 2) was replaced by an expression cassette containing a loxP site, a modified human ACE2 cDNA, loxP site, woodchuck hepatitis virus posttranscriptional regulatory element (WPRE), SV40 polyA signal, and FRT-flanked PGK-neomycin resistance gene via CRISPR/Cas9 technology. The human ACE2 cDNA was modified to use the mouse Ace2 signal peptide and codon-optimized for a mouseThe first loxP site interrupts the 5 untranslated sequence of the mouse Ace2. (J:337814)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
