LoxP sites were inserted into introns 1 and 3, closely flanking exons 2 and 3. An Frt-PGK-NeoR-Frt selection cassette was placed immediately 5 of the LoxP site in intron 3. FLP-mediated recombination removed the selection cassette in the germline. (J:298172)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count