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EN
CRISPR/Cas9 genome editing technology was used to generate an insertion of a codon optimized 3x FLAG tag sequence followed by SV40-NLS sequence, an mNeongreen sequence followed by an SV40-NLS and 6-His tag sequences. After selection of guide RNAs as closest as possible to the IL-18 gene start and stop codons, all IL-18 sequences between start and stop codon (exons 2-6) were replaced by the mNeongreen cassette. (J:337717)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
