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CRISPR/cas9 gene editing uses two guide RNAs to insert loxP sites around the promoter and full coding sequence. The 5'sgRNA (GGACAACGTGGGCAAAACTG) is designed to target chromosome 6 (Chr 6) coordinates 86,526,355 to 86,526,374 (Mus musculus genomic assembly mm10), and the 3'sgRNA (AGCACCCCATACTTAAAACA) targeted to Chr 6, positions 86,524,407 to 86,524,426. (J:337554)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
