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The targeting vector was designed to insert an expression optimized iBE reporter construct downstream of the Col1a1 locus. The construct contains a tetO promoter, an optimized BE3RA and rabbit beta globin polyA (RBGpA) sequence. BE3RA contains a rat APOBEC cytidine deaminase at the N-terminus of inactive dCas9 (Cas9-D10A) and a uracil glycosylase inhibitor (UGI) domain at the C-terminus. (J:337058)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
