A loxP site was inserted upstream of exon 3 and a second loxP site and FRT-flanked neomycin resistance gene were inserted downstream of exon 4. The neomycin resistance gene was removed via flp-mediated recombination leaving exons 3-4 floxed. (J:336297)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count