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CRISPR/cas9 genome editing is used to delete the 11qC region of the mouse genome between chr11:83791635-84938224 Mb [GRCm38.p6 (mm10), NCBI Reference Sequence, NC_000077.6]. The mouse deletion matches the consensus human deletion between chr17:31.8-33.2 Mb (GRCh38.p13, NCBI Reference Sequence, NC_000017.11). The 17q12 deletion removed all genes downstream of Gm11434 and upstream of Gm33028 including Aatf, Acaca, Gm11437, Ddx52, Dhrs11, Dusp14, Ggnbp2, Lhx1, Hnf1b, Mrm1, Myo19, Pigw, Synrg and Znhit3. sgRNAs were targeted to upstream of Hnf1b and downstream of Znhit3. (J:334297)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
