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The topologically associating domain (TAD) boundary region or insulator between Sim1 and Lilrb4b, separating the Sim1 TAD from the Rfx6 TAD, was targeted with sgRNAs (targeting TATAGCTGAATAAGTATACAGGG, TGAACTTGAACAGAGAAATGGGG, CTTGTTGCCTGCTCTGTAGGTGG and TGATTGGTAGGAGCAGAAACAGG) using CRISPR/Cas9 technology, resulting in a 19621 bp deletion (chr10:51280274-51299894 (GRCm39)). (J:335096)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
