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EN
The topologically associating domain (TAD) boundary region or insulator between Ctif and Zbtb7c, separating the Smad7 TAD from the Smad2 TAD, was targeted with sgRNAs (targeting TAAGATCTGTGCTACGGGGGGGG, CATCTGGCTAGCTCAATACACGG, CAATGGGATCTCCTTGGTCCTGG and CAAGCAGGGCAAGGGAGATTGGG) using CRISPR/Cas9 technology, resulting in a 72070 bp deletion (chr18:75847706-75919775 (GRCm39)). (J:335096)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
