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Two point mutations, chr6:31197455G>A and chr6:31197457A>T (GRCm39), were created using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutations in intron 1 eliminate the exon 1 splice donor site, changing it from from G-GTA to G-ATT, which virtually eliminates transcript expression from this allele. (J:324861)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
