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CRISPR/Cas9 technology deleted exons 9-12 which encodes for the Fz-like domain. DNA sequencing confirmed the joining of introns 8 and 12, deletion of exons 9-12, and in-frame splicing of RNA encoded by exons 8 and 13. Three founder lines were generated which contain small deletions (2, 11, or 18 bp) at the break sites in introns 8 and 12. This record is a representative line that contains the 2 bp deletion in addition to the exon 9-12 deletion. (J:232554)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
