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CRISPR/cas9 genome editing uses two guide RNAs (GCTGCGATCCGAACAGTGAG and TCGATCCTCATACATTTCAT) to delete a 47 kb region of mouse chromosome 14, including both Gm41148 and Gm35360, (mm39 chr14:48,019,230-;48,066,441) which corresponds to the human long intergenic non-protein coding RNA 520 locus (LINC00520). This region is also referred to as enhancer-associated long non-coding RNA (lncRNA) that enhances endothelial nitric oxide synthase expression (LEENE).
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
