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A guide RNA (GAAGCACTGGGGGAGGCACA) is designed to create a CAC to CGC mutation at position 47, restoring the R47H mutation to the wild-type derived H47R. ssODN repair template, gRNA, tracrRNA and CAS9 nuclease were introduced sequentially into the cytoplasm of C57BL/6-Trem2em2(TREM2*R47H)Aduci-derived zygotes with well recognized pronuclei. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
