Log In|Sign Up
EN
CRISPR/Cas9 technology targeting the ZnF7 domain generated two cysteine to alanine point mutations at residues 764 and 767: TGC to GCC (p.C764A) and TGC to GCT (p.C767A). Two silent mutations [GCC to GCT (A758) and TAC to TAT (Y768)] were also introduced to avoid re-editing. These mutations abrogate binding ability to polyubiquitin chains. (J:282944)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
