Log In|Sign Up
EN
Serine codons 22 (TCT), 25 (AGC) and 28 (TCC) were targeted for mutation to alanine codons (GCT, GCC, GCT) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This allele contains all three mutations (p.S22A, p.S25A, p.S28A (p.S3A, p.S6A, p.S9A in mature protein)). The mutations block phosphorylation of the residues in the encoded peptide. (J:326013)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
