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The transgene insert contains the following elements: 3 kb TAGLN gene proximal promoter sequence, mutated mouse Mgp cDNA and SV40 poly(A) signal sequences. The mutations involve changing glutamic acid codons 21, 60, 67 and 71 (GAA, GAA, GAG, GAG) to alanaine (GCA, GCA, GCG, GCG) (c.62A>C, c.179A>C, c.200A>C, c.212A>C, p.E21A, p.E60A, p.E67A, p.E71A), which prevents gamma-carboxylation of these residues in the encoded peptide. (J:326013)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
