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A loxP site was inserted in exon one 5' of the N-terminal region and a loxP and FRT flanked neo cassette was inserted 3' of exon 1. Cre mediated recombination removed the neo cassette and the N-terminal region of exon 1. Western blot analysis confirmed the absence of expression of the RUNX3(P1) protein that has a distinct set of 19 N-terminal amino acids compared to the RUNX3(P2) protein. (J:319454)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
