Exon 4 was flanked by loxP sites. An adjacent frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in ES cells prior to the creation of mice. (J:255626)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count