CRISPR/cas9 genome editing is uses two guide RNAs [5';-GTCGCCGCTAGCCTGG-30 and 50- GATTTGGAGATTCAGGC-3';] to target exons 1 and 2 of the gene. Western blot analysis confirmed the absence of protein. (J:335286)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count