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Serine codon 68 (AGC) was changed to alanine (GCT) (p.S68A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation prevents phosphorylation of the highly conserved residue, which is normally phosphorylated by MAPK. (J:327336)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
