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CRISPR/cas9 endonuclease-mediated genome editing is used to create an aspartate to alanine substitution at codon 262 in exon 2. The mutation is changes the aspartate residue needed for cellular DNA activity to an inactive alanine. The crRNA and tracrRNA sequences are as follows; crRNA #1 for D/A on Exon 2, sequence (AGCCACTCTGCAGGGAGTCG), crRNA #2 for D/A on Exon 3, sequence (ACATGAACCCCTGATTGACG); tracrRNA. (J:335226)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
