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The transgene consists of 2xcHS4(chicken b-globin insulator)-ROSA26 promoter-splicing acceptor-CreN59-nMag-Nuclear localization signal-2PA-Nuclear localization signal-pMag-CreC60-poly A sequence-2xcHS4r(chicken b-globin insulator). The nMag and pMag are part of Magnets protein derived from the fragments of photoreceptor gene product Vivid (VVD) from a filamentous fungi Neurospora crassa. This transgene contains photo-switchable magnet proteins which can reassemble split Cre proteins by light-induced dimerization when exposed to blue light. Four of the six founder lines showed light-dependent Cre-mediated DNA recombination and line 3 was established. (J:320899)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
