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CRISPR/Cas9 technology generated a histidine to lysine substitution at amino acid 353 (p.H353K) in exon 9. K353 is a residue at the core of the ACE2-RBD interaction in humans which has been shown to allow replication of the original SARS coronavirus in mouse cells. (J:335150)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
