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Aspartic acid codon 398 (GAT) in exon 6 was changed to asparagine (AAT) (p.D398N) using an sgRNA (targeting CCGCGCYCGATTGCATTCGCTAC) and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of human SNP rs16969968 (p.D398N) associated with nicotine and opiate dependence. (J:342737)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
