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The donor constructed mice with a 1.4-Mb duplication or deletion on mouse chromosome 7C syntenic with the human 15q13.3 region by gene targeting and trans-allelic recombination in vivo. LoxP sites were inserted into the mouse genome by gene targeting to flank the region to duplicate or delete following cre-mediated recombination. Selectable markers were deleted by Flp/FRT-mediated recombination prior to combining the loxP alleles in the animal. (J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
