This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TCAGCTCCTTTTTTTTTCTG and GCGAGACCAATGGGGAGACG, which resulted in a 12794 bp deletion beginning at Chromosome X position 56,585,378 bp and ending after 56,598,171 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000436074, ENSMUSE00000364351, ENSMUSE00000412050, ENSMUSE00000366591 (exons 1-4) and 8560 bp of flanking intronic sequence including the splice acceptor start site and splice donor and is predicted to result in a null allele. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
Intragenic deletion
Not Specified
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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