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LoxP site was inserted into intron 7 together with a self-excision neomycin cassette flanked by Rox sites and a second loxP site was inserted into intron 8. The neomycin cassette was self-excised. Exon 8 was deleted via cre-mediated recombination in the germline. RT-PCR confirmed the in-frame deletion of the central domain (exon 8). Western blot analysis using an antibody against the middle domain confirmed its absence. (J:328987)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
