A neomycin and LacZ cassette together with loxP sites flanking exon 4 and 5 were inserted by homologous recombination. A null/knockout allele was created by subsequent flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exons 4 and 5. (J:252765)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count