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Exon 6 was targeted with an sgRNA (targeting GGTTGTGAGCGCAGGCATGC) and an ssODN template (ACAGCCAAAAATCTCGATTGTTTCTCCTTAGAAAATCCCAGAGCAGAGTGTCTTATTACACGCATGTGCACACAACCCCACCGGCGTGGACCCGCGTCCCGAGCAGTGGAAGGAGATAGCGTCCG) using CRISPR/Cas9 technology to delete one of leucine codons 207, 208 or 209 (p.L209del). The equivalent human mutation (p.Leu209del, NM_002080.2:c.624_626delTCT) is found in some Malate-Aspartate Shuttle (MAS)-Related Encephalopathy patients. (J:291216)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
