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Exon 1 was targeted with an sgRNA and ssODN template using CRISPR/Cas9 technology to change aspartic acid codon 24 (GAC) to asparagine (AAC) (p.D24N). The mutation mimics the human NM_022770.2: c.70G>A, p.(Asp24Asn) mutation found in some Meier-Gorlin syndrome patients. (J:331868)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
