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A guide RNA [5'- GCAGATCACGAGGGAAGAGG-3'] is selected to introduce a full-length luciferase gene, containing the R387X (c.A1159T) nonsense mutation and T381T silent mutation, into the Gt(ROSA)26Sor locus. The silent T381T mutation creates a new PAM site required for the binding of the base editor. (J:334636)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
