The targeting cassette includes a loxP-Stop-loxP cassette, a neomycin-resistance gene integrated with the Stop cassette for positive selection. The insertion of this cassette in intron 1 results in disruption of the endogenous gene and no mouse Rgr is expressed. (J:101977)
Basic Information
Disruption caused by insertion of vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count