A loxP site was inserted upstream of exons 7 and 8. An Frt-flanked neomycin selection cassette was inserted downstream of exon 8, followed by a second loxP site. Exons 7 and 8 are thus flanked by loxP sites. (J:295291, J:334073)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count