The EUCOMM targeting vector PRPGS00036-W-3-B04 was used to create this knock-out allele. The vector replaces exon 4 with an FRT site, lacZ sequence, loxP site, neomycin resistance gene under the control of the human beta-actin promoter, FRT site, and loxP-flanked exon 4. The lacZ and neomycin were removed via flp-mediated recombination. Exon 4 was deleted via cre-mediated recombination. (J:288987)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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