Using CRISPR/Cas9 technolgy, the CrexER (Cre-rox-ER-rox) was generated by the insertion of two rox sequences flanking ERT2, a cDNA encoding CrexER recombinase replaced the translational stop codon of the Mki67 gene, following endogenous Mki67 by the self-cleaving peptide 2A sequence. (J:303771, J:339117)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count