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CRISPR/Cas9 technology using sgRNAs 5 AATATGTGGGCAAGCTGGGTTGG 3 AND 5GAAATGGTACCTTTGATTAAGG 3 generated an approximate 20 kb deletion at intron 17. This is similar to a deletion identified in an individual on the autism spectrum. Both Nrxn1alpha and Nrxn1gamma transcript levels are unaffected while Nrxn1beta levels are slightly reduced in homozygous males but not in females. (J:334083)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
