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A targeting vector was designed to insert a FRT site and the human BRAF cDNA covering exons 15-18 into intron 14, along with a PGK-neo STOP cassette and a second FRT site. A modified exon 15 was engineered into the vector to encode Braf with a valine to glutamate substitution at amino acid 600 (p.V600E) and a silent XbaI restriction site. (J:225607)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
