Log In|Sign Up
EN
CRISPR/cas9 endonuclease-mediated genome editing is used to target close to the start codon of isoform I and III. The founder contains a 1 nucleotide deletion at the beginning of the open reading frame resulting in a frame shift at residue 33 that produces a stop codon at amino acid 40. Western blot confirms the loss of isoform I. It is not clear if isoforms II and III are affected. (J:240578)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
