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A cre/ERT2 fusion protein was inserted into a BAC clone (RP23-279P6) containing 200kb sequences including the transcriptional regulatory elements of the Alb (albumin) and Afp (a-fetoprotein) genes in their original chromosomal arrangement. Recombination inserted the CreERT2 cassette within Alb exon1, thereby disrupting Alb coding sequences on the BAC but preserving the promoter and relevant 5 regulatory elements. The expression is restricted to the liver only with tamoxifen-inducible activation. (J:317522)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
