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The CAG promoter (chicken beta-actin promoter with CMV enhancers) was used to drive expression of a gene encoding nuclear localized FLPe recombinase. Five founder lines were established (lines 16, 32, 36, 37 and 41), of which lines 16, 32 and 36 exhibited 100% recombination when crossed to a mouse bearing a frt-flanked cassette; 10/11 mice of line 37 showed recombination. Mosaicism was noted in 2/9 of line 16 and in 1/8 of line 32 double transgenic mice. (J:108559)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
