The Vsx2 enhancer, part of super-enhancer Rr272, was targeted with sgRNAs (targeting GTTAGACCTAGTCAGAACTC and TACTTCAGACTCTGGCTCCA) using CRISPR/Cas9 technology, resulting in a 789 bp deletion (chr12:84578820-84579608 (GRCm39)). (J:333875)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F1
Endonuclease-mediated
Intergenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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