The targeting construct inserted a loxP site upstream of exon 3 and an FRT- and loxP-flanked neomycin resistance cassette downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:333563)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count