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EN
Exon 3 was replaced with a floxed neo/STOP cassette and a modified exon 3 in which nucleotide substitution (GAA to AAA) results in the amino acid substitution of lysine for glutamic acid at position 76 (E76K), mimicking a mutation found in some childhood acute leukemia and juvenile myelomonocytic leukemia (JMML) patients. Cre-mediated recombination removed the floxed stop cassette. (J:332221)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
