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The transgene insert contains the following elements: the 5' PiggyBAC transposon inverted repeat, Atoh1 enhancer E1, Hsp68 minimal promoter, beta-galactosidase reporter gene, SV40 early poly(A) signal sequences, and the 3' transposon inverted repeat. The transgene was injected into single-cell zygotes together with PiggyBAC transposase mRNA to facilitate integration into the genome. Several independent transgenic mouse lines were established. The reporter is expressed in the spinal cord and other neurological tissues during embryonic development. (J:332270)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
