Atoh1 enhancer Eh2 or E3 was targeted with sgRNAs (targeting TATGAACTAGAATATTGTATTGG and AACGTATTCAAAGTCAAAGCGGG) using CRISPR/Cas9 technology, resulting in a 2519 bp deletion (chr6:64774536-64777054 (GRCm39)) including the enhancer. (J:332270, J:333396)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
Endonuclease-mediated
Intergenic deletion
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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