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The Zbtb7b silencer was targeted with an ssODN template, coding for the first 250 bp of the silencer sequence in reverse orientation, using TALEN technology (ZNF target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG). The resulting allele has the 5' (distal) end of the silencer flipped, while the 3' (proximal) end, containing a highly conserved noncoding element (HCNE), remains in the normal orientation. (J:333471)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
