The Zbtb7b silencer was targeted with an ssODN template, coding for a version of the silencer sequence where a 40 bp sequence of a highly conserved noncoding element (HCNE; located at the 3' end) containing two conserved Runx binding motifs is moved to the 5' end, using TALEN technology (ZNF target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG). (J:333471)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count