CRISPR-targeting using sgRNAs (targeting GGTCGGGAAGCCAGAAGGTTCT and GGTCTTCATTCCTAGAACCTTC) deleted 11 bp (GGTTCTAGGAA), which includes the interferonactivated sequence (GAS) motif, within the E3 enhancer (part of Wap super enhancer) upstream of Wap. (J:277922)