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A targeting vector consisting of a cassette containing ERT2-Cre-recombinase genes with frt-PGK-neomycin (neo)-bpA-frt was used for homologous recombination in ES cells using the CRISPR-Cas9 system to replace the exon 1 of the Sfrp5 gene. Frt-neo was then removed by crossing with Rosa-Flp mice. (J:245018)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
