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CRISPR/Cas9 technology using sgRNA 5-gGAATGGCCTGTGGTTGACT-3 (5 mismatch indicated by lowercase g) generated mice harboring a sequence with stop codons in all reading frames in exon 2. The stop cassette inserted at genomic position GRCm38/mm10 chr2:128,729,258 has the following sequence: 5-cgcTAAgTGAcTGAccaccgc-3 (Stop codons in upper case, flanking homology sequences are not included). (J:288823)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
